Il potere come dimensione politica e antropologica nel romanzo «Cox oder Der Lauf der Zeit» (2016) di Christoph Ransmayr: [Power as political and anthropological dimension in the novel «Cox or the Course of Time» (2016) by Christoph Ransmayr]

The essay analyses the characterisation of power in Christoph Ransmayr’s novel Cox oder Der Lauf der Zeit. Specifically, power is analysed on its political level, with the social implications that it necessarily entails on both the human and personal level, showing the individual in charge locked in the solitude of his distance from others; and on its gender level, which is expressed in the novel by the subjugation of the female to the male. In conclusion, nature and time in the novel are highlighted in their function as obstacles to limitless power

Ultrabiomicroscopy anterior segment evaluation of ocular contusive trauma caused by pressurized bottled drink caps. a case report

We report the case of a patient presented to the emergency department because of a contu-sive trauma from a pressurized bottled drink cap. During the visit, the patient indicated that he had been hit in his left eye by a cork while he was opening a sparkling wine bottle. He underwent a total ophthalmology examination. He had an important reduction of visual acuity, corneal swelling, Descemet’s folds, and hyphema. Therefore, we decided to perform ultrabio-microscopy (UBM) of the anterior segment to study the endothelial damage and Descemet’s membrane. UBM images confirmed the direct biomicroscopy, highlighting the damaged loca-tion

Ocriplasmin in the treatment of vitreomacular traction in a patient with central retinal vein occlusion. a case report

Aim: To investigate the efficacy of intravitreal injection of ocriplasmin (JETREA®) in the treat-ment of vitreomacular traction (VMT). Materials and Methods: An 81-year-old man with VMT associated with central retinal vein occlusion in his left eye, was treated with a single intravitreal injection of ocriplasmin (25 μg). Best corrected visual acuity (BCVA), ocular fundus, and optical coherence tomography were examined before and after treatment. Results: Complete release of VMT produced a reduction of central macular thickness, ranging from 459 to 141 μm. BCVA remained stable. Discussion and Conclusions: The use of ocriplasmin was effective in the treatment of VMT. Ocriplasmin represents a valid alternative to conventional pars plana vitrec-tomy

The unexpected for the expecting parent: Effects of disruptive early interactions on mother-infant relationship.

High-quality parental caregiving promotes children’s development from their day of birth or even earlier. Whether or not there are ways to predict, and ultimately enhance, parental caregiving quality during the prenatal stages of development has been less well understood. This is even truer when things do not go according “to plan”. In this commentary, we explore two possible scenarios, perhaps unexpected for expectant parents, that can affect children’s development: (1) postpartum parental displays of atypical behaviors and parental caregiving strategies (i.e., maternal/paternal depression) and (2) postpartum child displays of atypical behaviors (i.e., autism spectrum disorder). Keywords: Postpartum Depression; Autism Spectrum DisorderBetty Behrens Research Fellowship, Clare Hall Cambridge

Risk factors associated with the occurrence of autoimmune diseases in adult coeliac patients

Objectives. Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly investigated. The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of adult coeliac patients. Materials and Methods. We performed a single-center case-control study including adult newly diagnosed CD patients. To evaluate the risk factors of the association between AD and CD, 341 coeliac patients included were categorized on the basis of AD presence: 91 cases with at least one AD and 250 controls without AD were compared for clinical, serological, and histological features. Eighty-seven cases were age-gender-matched with 87 controls. Results. Among 341 CD patients, 26.6% of CD patients had at least one AD. Endocrine and dermatological diseases were the most prevalent AD encountered: autoimmune thyroiditis was present in 48.4% of cases, psoriasis in 17.6%, and type I diabetes and dermatitis herpetiformis in 11%, respectively. At logistic regression, factors associated with AD were a positive 1st-degree family history of AD (OR 3.7, 95% CI 1.93–7), a body mass index ≥ 25 kg/m2 at CD diagnosis (OR 2.95%, CI 1.1–3.8), and long standing presentation signs/symptoms before CD diagnosis (>10 years) (OR 2.1, 95% CI 1.1–3.7). Analysis on age-gender-matched patients confirmed these results. Conclusions. CD patients with family history of AD, overweight at CD diagnosis, and a delay of CD diagnosis had an increased risk of having another AD. The benefit of CD screening in these specific subsets of patients with AD awaits further investigation

Singles’ Reasons for Being Single:Empirical Evidence From an Evolutionary Perspective

A relatively large number of people in Western societies are single; that is, they are not involved in any romantic relationship. In this study, we have attempted to investigate the reasons for singlehood by asking singles themselves. A final sample of 648 American singles (307 of them women) rated 92 possible reasons for singlehood. These reasons were classified into 18 broad factors and four general domains. Among the most important reasons were poor flirting skills, freedom, fear of getting hurt, having different priorities, and being too picky. Significant sex and age effects were found across different factors and domains. More specifically, men were more likely than women to indicate that they were single in order to be free to flirt around, and because they were not into family making; while women were more likely to indicate that they were single in order to avoid getting hurt, and because they have considered themselves not to be desirable as mates. Younger people were more likely to indicate that they were single because they had poor flirting skills, because they did not see themselves as desirable mates, and because they did not like commitment; whereas older people were more likely to indicate that they were single in order to be free to do what they have wanted. Findings were examined and discussed using evolutionary theories relating to mate selection and evolutionary mismatch.Nanyang Technological UniversityPublished versionThis study was supported by the Nanyang Technological University’s NAP-SUG scheme that was awarded to GE

Upper gastrointestinal symptoms in autoimmune gastritis. A cross-sectional study

Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features. Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria. Association between symptoms and anemia pattern, positivity to gastric autoantibodies, Helicobacter pylori infection, and concomitant autoimmune disease were evaluated. In total, 70.2% of patients were female, median age 55 years (range 17-83). Pernicious anemia (53.6%), iron deficiency anemia (34.8%), gastric autoantibodies (68.8%), and autoimmune disorders (41.7%) were present. However, 56.7% of patients complained of gastrointestinal symptoms, 69.8% of them had exclusively upper symptoms, 15.8% only lower and 14.4% concomitant upper and lower symptoms. Dyspepsia, subtype postprandial distress syndrome was the most represented, being present in 60.2% of symptomatic patients. Univariate and multivariate analyses showed that age <55 years (OR 1.6 [CI:1-2.5]), absence of smoking habit (OR 2.2 [CI:1.2-4]), and absence of anemia (OR 3.1 [CI:1.5-6.4]) were independent factors associated to dyspepsia. Autoimmune gastritis is associated in almost 60% of cases with gastrointestinal symptoms, in particular dyspepsia. Dyspepsia is strictly related to younger age, no smoking, and absence of anemia. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc

Technological and theoretical aspects for testing electroporation on liposomes

Recently, the use of nanometer liposomes as nanocarriers in drug delivery systems mediated by nanoelectroporation has been proposed. This technique takes advantage of the possibility of simultaneously electroporating liposomes and cell membrane with 10-nanosecond pulsed electric fields (nsPEF) facilitating the release of the drug from the liposomes and at the same time its uptake by the cells. In this paper the design and characterization of a 10 nsPEF exposure system is presented, for liposomes electroporation purposes. The design and the characterization of the applicator have been carried out choosing an electroporation cuvette with 1 mm gap between the electrodes. The structure efficiency has been evaluated at different experimental conditions by changing the solution conductivity from 0.25 to 1.6 S/m. With the aim to analyze the influence of device performances on the liposomes electroporation, microdosimetric simulations have been performed considering liposomes of 200 and 400 nm of dimension with different inner and outer conductivity (from 0.05 to 1.6 S/m) in order to identify the voltage needed for their poration

Geological constraints for a conceptual evolutionary model of the slope deformations affecting Mt. Nuovo at Ischia (Italy)

ischia island was the scenario of several Holocene slope in- stability events occurred at different scales, from shallow mass movements, triggered by meteo-climatic forcing, up to massive rock slope failures such as large debris avalanches these last ones related to the volcano-tectonic dynamics of a resurgent caldera. the present study focuses on the gravitational deformation that in- volves Mt. nuovo, located in the western portion of Mt. epomeo resurgent block. a high-resolution engineering-geological model was reconstructed according to a multi-modelling approach sup- ported by field geo-structural evidences and constrained by pas- sive seismic investigations. it revealed a complex morpho-struc- tural setting and led to the identification of a multiple compound mechanism, involving a rock mass volume of about 190 million of cubic meters. the obtained geological model shows a partial structural control of the pre-existing tectonic pattern on slope deformation mechanisms, highlighting geometric and volumetric similarities between the Mt. nuovo ongoing deformation and an already oc- curred rock avalanche. the defined conceptual evolutionary mod- el allows to hypothesize the role of inner pressures constraining the shear zone initiation and propagation and making reliable a future scenario of generalized collapse. Starting from these new field and laboratory data, numerical models will be reconstructed in order to depict the evolution of the gravitational slope deformation, evaluate its sensitivity and constrain future evolutionary instability scenarios